Once you have created your account you can sign in to your myNCBI account
When you are signed into your myNCBI account at the home page you will see a number of boxes that contain information of interest. To set alerst you can click on theSearch NCBI Databases box, PubMed should be showing in the search field. If not select PubMed from the dropdown menu window and click the Search button to go to PubMed.
Search for the keywords, Authors or titles you are interested in setting up an alert for from the search box
If search returns useful information and you want to create an alert click Save Search
This will allow you to create a name for your saved search
Select which email address you want the alert to be sent to (the default is the email address associated with the myNCBI account but you can change the address here).
Select the frequency you wish to recieve the alert email
Select the number of items you wish to receive in each email
You will be directed back to your myNCBI main page. In the Saved Searches box you will see your new saved search/alert.
If you click on the cog you can access the settings for each saved search/alert so you can alter them as required.